王利振

发布时间:2020-07-03作者:出处:生物工程学院责任编辑:田中建

王利振个人信息

姓    名

王利振

性    别

籍    贯

山东济南

出生年月

1984.11

职    称

副研究员

政治面貌

群众

专    业

生物与医药

职    务

导师类别

硕导

学历、学位

研究生、博士

课 题 组

山东省斑马鱼人类疾病模型与药物筛选工程技术研究中心

工作信息

手机:15866683436;邮箱:wlzh1106@126.com

隶属单位

山东省科学院生物研究所  

通讯地点

济南市历城区经十东路28789

学习、工作简历:

2003.9-2007.6  山东轻工业学院应用化学专业,获工学学士学位;

2007.9-2010.6  山东轻工业学院应用化学专业,获工学硕士学位;

2010.7-2012.8  山东轩竹医药科技有限公司,研究员;

2012.9-2016.6 山东大学生命科学学院生物化学与分子生物学专业,获理学博士学位;

2016.9-2017.5  济南山目生物医药科技有限公司;

2017.07-2019.03  山东省科学院生物研究所实习;

2019.4-至今  齐鲁工业大学(山东省科学院)生物研究所。


主要研究方向:

课题

山东省自然科学基金项目“天然糖类模块修饰的小檗碱衍生物及其在斑马鱼模型下的降血糖构效关系研究”;

生物基材料与绿色造纸国家重点实验室开放基金“聚乙二醇化的纳米淀粉颗粒的制备及其用作抗肿瘤药物载体的研究”;

论文:

(1) Wang, L.; Kong, H.; Jin, M.; Li, X.-B.; Stoika, R.; Lin, H.-w.; Liu, K.* Synthesis of disaccharide modified berberine derivatives and their anti-diabetic investigation in zebrafish using a fluorescence-based technology. Organic & Biomolecular Chemistry, 2020, 18, 3575. (IF = 3.490)

(2) Wang, L.; Zhang, J.; An, X.; Duan, H.* Recent progress on the organic and metal complex-based fluorescent probes for monitoring nitric oxide in living biological systems. Organic & Biomolecular Chemistry 2020, 18, 1522. (IF = 3.490)

(3) Zhang, B.;#Wang, L.;# Ji, X.;# Zhang, S.; Sik, A.; Liu, K.; Jin, M.* Anti-Inflammation Associated Protective Mechanism of Berberine and its Derivatives on Attenuating Pentylenetetrazole-Induced Seizures in Zebrafish. Journal of Neuroimmune Pharmacology,2020, 15, 309–325. (IF = 3.87)

(4) Meng Jin, Xiuna Ji, Rostyslav Stoika, Kechun Liu, Lizhen Wang,* and Yang Song. Synthesis of a novel fluorescent berberine derivative convenient for its subcellular localization study. Bioorganic Chemistry, 2020, DOI: 10.1016/j.bioorg.2020.104021. (IF = 3.926)

(5) Liwen Han, Wenlong Sheng, Xiaobin Li, Attila Sik, Houwen Lin, Kechun Liu,* Lizhen Wang*. Novel carbohydrate modified berberine derivatives: Synthesis and in vitro anti-diabetic investigation. MedChemComm, 2019, 10, 598–605. (IF= 2.342)

(6) Geng Yang, Xia Meng, Shimin Fang, Hongdong Duan,* Lizhen Wang,* Zhenzheng Wang. A highly selective colorimetric fluorescent probe for detection of Hg2+ and its application on test strips. RSC Adv., 2019, 9, 8529–8536. (IF= 2.936)

(7) Lizhen Wang, Shaojie Feng, Subo Wang, Hui Li, Zhongwu Guo*, and Guofeng Gu*, Synthesis and Immunological Comparison of Differently Linked Lipoarabinomannan Oligosaccharide-Monophosphoryl Lipid A Conjugates as Anti-Tuberculosis Vaccines. J. Org. Chem., 2017, 82: 12085. (IF=4.849)

(8) Lizhen Wang, Shaojie Feng, Lian An, Guofeng Gu*, and Zhongwu Guo*, Synthetic and Immunological Studies of Mycobacterial Lipoarabinomannan Oligosaccharides and Their Protein Conjugates. J. Org. Chem., 2015, 80: 10060. (IF=4.805)

专利:

(1) 王利振,韩利文,刘可春,盛文龙,李晓彬,一种三氮唑糖修饰的小檗碱盐衍生物及其制备方法和用途,2019-09-27,中国,ZL201810711484.9

(2) 王利振,刘可春,韩利文,靳梦,李晓彬,一种鼠李糖或核糖修饰的小檗碱盐衍生物及其制备方法和用途,2019-07-23,中国,ZL201810722418.1


奖:

2014年 获全国糖生物学会议“优秀论文奖”

人才称号和荣誉:


社会兼职:

国际药物化学期刊Journal of Medicinal ChemistryMedicinal Research Reviews审稿人



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